| September 10, 2021 | Fargo South High School @ Valley City | Valley City High School | 21-18 |
| September 10, 2021 | Wahpeton High School @ Grand Forks Central High School | Cushman Field | 14-28 |
| September 10, 2021 | Fargo North High School @ Dickinson | Dickinson High School | 21-35 |
| September 11, 2021 | Grand Forks Red River @ Devils Lake Firebirds | Devils Lake High School | 3:00pm |
| September 11, 2021 | Grand Forks Red River @ Devils Lake Firebirds | Devils Lake High School | 7:00pm |